Tesamorelin is a synthetic analogue of growth hormone-releasing hormone (GHRH). Rather than supplying growth hormone directly, it stimulates the body's own pituitary release of growth hormone, subsequently influencing IGF-1 (insulin-like growth factor 1). Tesamorelin is best known clinically for its use in reducing excess visceral abdominal fat in adults with HIV-associated lipodystrophy. However, the relationship between growth hormone, IGF-1, body composition, metabolic health and longevity...

Many people try NAD+ injections hoping they'll experience a noticeable improvement in energy, only to come away disappointed. That was exactly the experience of the participant featured in this case study. Despite completing a course of NAD+, she described the overall effect as underwhelming. Her day-to-day fatigue remained significant, and simply getting out of bed in the morning continued to be a struggle. Her experience with MOTS-c, however, was very different. Rather than producing a...

Introduction Mitochondrial dysfunction is increasingly recognised as one of the earliest drivers of ageing, metabolic disease and declining physical performance. As the cell's energy-producing organelles become less efficient, oxidative stress rises, ATP production falls, and tissues with high energy demands—including the heart, kidneys, brain and skeletal muscle—become increasingly vulnerable. One peptide attracting growing interest in longevity and mitochondrial research is SS-31, also...