Case Study: Reversing Chronic Inflammation with Mounjaro & Curcumin

Chronic, low-grade inflammation is one of the most underestimated drivers of accelerated ageing, metabolic dysfunction, and long-term disease risk. While weight-loss drugs such as Mounjaro (tirzepatide) are often seen as a quick fix, this case study highlights how strategic synergy—combining pharmacology, targeted supplementation, lifestyle optimisation, and epigenetic testing—can lead to profound and measurable improvements in inflammatory health.

Using DNA methylation–based inflammatory markers rather than short-term blood tests, this client achieved a dramatic and stable reduction in chronic inflammation, as shown in the image below.

Measuring Inflammation Properly: Why Epigenetic Testing Matters

Traditional blood markers like CRP and IL-6 are highly reactive. They fluctuate with sleep, training, stress, or even a mild infection. In contrast, DNAm CRP and DNAm IL-6 reflect long-term inflammatory signalling encoded at the epigenetic level.

This is why epigenetic testing is increasingly being used as a true health MOT, rather than a snapshot.

In this case:

• DNAm CRP dropped significantly over time

• DNAm IL-6 reduced to an optimal, balanced range

• Improvements were benchmarked against population norms matched for age and sex

This level of insight is only possible with advanced epigenetic testing, such as TruAge and TruHealth by TruDiagnostic.

Epic Genetics is an official UK TruDiagonstoic distributor and provider of epigenetic tests, making this level of analysis accessible in the UK for the first time at scale.

Mounjaro (Tirzepatide): More Than Weight Loss

Mounjaro works by activating GLP-1 and GIP receptors, improving insulin sensitivity, appetite regulation, and—crucially—visceral fat loss.

Visceral fat is not just passive energy storage. It is a metabolically active tissue that secretes inflammatory cytokines, including IL-6.

By drastically reducing visceral fat, Mounjaro likely played a central role in:

• Lowering systemic IL-6 signalling

• Reducing chronic inflammatory load

• Improving metabolic-immune cross-talk

This is why the client’s DNAm IL-6 did not just fall—but normalised, reaching a level associated with optimal immune readiness rather than immune suppression.

Importantly, this case also highlights a key nuance:

Some IL-6 is necessary.IL-6 plays a role in immune activation, infection response, and exercise adaptation. The goal is balance, not elimination—and this client achieved exactly that.

Longvida® Curcumin: Epigenetic Anti-Inflammation Done Right

Curcumin is widely known for its anti-inflammatory effects, but most formulations suffer from poor bioavailability. Longvida® Curcumin is different.

It is specifically designed to:

• Cross the blood–brain barrier

• Remain bioactive for longer

• Modulate NF-κB, COX-2, and inflammatory gene expression

• Influence inflammation at the epigenetic level

When paired with Mounjaro, Longvida® Curcumin likely amplified the reduction in chronic inflammation by:

• Further suppressing inflammatory signalling from adipose tissue

• Reducing oxidative stress associated with rapid fat loss

• Supporting endothelial and metabolic health

Timing Matters: Curcumin & Exercise

One important optimisation point in this case was not taking curcumin close to exercise.

Why?

• Exercise-induced inflammation is beneficial

• It drives mitochondrial adaptation and muscle remodelling

• Blunting this signal too aggressively can impair long-term gains

By separating Longvida® Curcumin from training windows, the client maintained:

• Exercise adaptation

• Metabolic flexibility

• Anti-inflammatory benefits without compromising performance

  
  

Fixing Nutritional Deficiencies with TruHealth

Rather than relying on short-term blood markers, TruHealth uses DNA methylation patterns to assess how efficiently key systems are functioning over time — particularly those involved in fat oxidation, mitochondrial energy production, appetite regulation, and inflammatory control.

In this case, the focus was on supporting pathways that would allow him to maintain fat loss and metabolic health while gradually scaling down his Mounjaro dose, rather than becoming dependent on pharmacology alone.

Key pathways optimised included:

• Fatty acid oxidation pathwaysEpigenetic markers such as palmitoylcarnitine provide insight into how efficiently fatty acids are transported into mitochondria for energy. Optimising this pathway supports sustained fat utilisation rather than rebound weight gain.

• Mitochondrial function and energy productionMarkers related to ATP synthase activity, ketone utilisation, and mitochondrial stress helped guide interventions to improve metabolic flexibility — critical when appetite suppression from GLP-1 agonists is reduced TruHealth Report AS-2.

• Leptin and satiety signallingEpigenetic leptin markers highlighted how effectively fat mass was communicating with the brain. Improving leptin sensitivity reduces post-diet hunger signals and supports appetite control independent of medication TruHealth Report AS-2.

• Ketone and metabolic switching capacityTruHealth data around beta-hydroxybutyrate (BHBA) helped assess how easily he could transition between glucose and fat-based fuel sources — a key factor in preventing metabolic slowdown during dose reduction TruHealth Report AS-2.

• NAD+ metabolism and cellular energy resilienceNAD+-related epigenetic markers provided insight into cellular repair capacity and energy efficiency, supporting long-term metabolic health rather than short-term weight loss alone TruHealth Report AS-2.

Importantly, this approach reframed supplementation and nutrition as pathway-specific tools, not generic add-ons — ensuring that every intervention supported the same goal: long-term metabolic independence.

Scaling Back Mounjaro with Epigenetic Feedback

Why Epigenetic Testing Matters When Scaling Back GLP-1 Agonists

One of the biggest challenges with GLP-1 agonists like Mounjaro is what happens after the dose is reduced.

By combining GLP-1 therapy with epigenetic testing, we can objectively assess whether the underlying drivers of inflammation and fat storage have actually been corrected — or merely suppressed.

In this client’s case, improvements in DNAm CRP and DNAm IL-6, alongside optimisation of fat-burning and mitochondrial pathways, provided confidence that inflammation was resolving at the biological systems level, not just at the scale or appetite level.

This allows for:

• Gradual dose reduction rather than abrupt cessation

• Lower risk of rebound inflammation or visceral fat regain

• Continued improvement in metabolic efficiency without escalating drug dependence

In other words, epigenetic testing turns GLP-1 agonists into a bridge, not a crutch.

By tracking long-term inflammatory and metabolic signalling through DNA methylation, we can personalise both when and how to scale back — something traditional blood tests simply cannot do reliably.

Drugs work best when they are supported—not relied upon.

The combination of:

• Mounjaro for visceral fat reduction

• Longvida® Curcumin for epigenetic inflammation control

• Exercise with intelligent timing

• Nutritional correction via TruHealth

• Progress tracking through epigenetic testing

resulted in large, stable improvements in chronic inflammation markers—far beyond what any single intervention would be expected to achieve alone.

Why This Matters for Long-Term Health

Chronic inflammation is linked to:

• Accelerated biological ageing

• Cardiovascular disease

• Neurodegeneration

• Metabolic dysfunction

By addressing inflammation at the epigenetic level, this client didn’t just improve numbers—they reduced future risk.

This is the power of using epigenetics as a preventative health MOT, rather than waiting for disease to appear.

Final Thoughts

Mounjaro is not “just” a weight-loss drug.Curcumin is not “just” a supplement. Epigenetic testing is not “just” another blood test.

When combined intelligently, they become a precision system for inflammation control and metabolic health.

If you want to understand what is really driving your ageing, inflammation, or metabolic health—and track whether your interventions are working—epigenetic testing through a UK TruDiagnostic provider is one of the most powerful tools available today.