"Why I've Become More Bullish on Tadalafil" Over the last few years, tadalafil has become one of the most discussed compounds within the longevity and biohacking community. While most people know it as a treatment for erectile dysfunction, emerging research suggests its benefits may extend far beyond sexual health. At Epic Genetics, we have become increasingly interested in tadalafil because of its potential effects on endothelial function, blood pressure regulation, vascular

Multiple sclerosis (MS) is a complex autoimmune condition affecting the central nervous system, but increasing research suggests the gut microbiome may play a major role in immune regulation, systemic inflammation, and neurological health. In this case study, we explore how advanced gut microbiome testing through Microbiotica and Enbiosis was used to identify inflammatory patterns, poor microbiome diversity, impaired mitochondrial-supportive pathways, and potential dietary in

When it comes to skincare, most products focus on the surface—hydration, exfoliation, or short-term improvements in appearance. But a new class of compounds is shifting attention deeper, targeting the cellular and mitochondrial drivers of skin aging. One of the most promising compounds in this space is SkQ1, a mitochondrial-targeted antioxidant designed to reduce oxidative stress at its source. In this article, we’ll explore how SkQ1 works, why it’s fundamentally different fr

Featuring Valentina Martinez-Perez, Social Media Manager, PT Medical Student Weight loss is often treated as a simple equation: eat less, move more, watch the number drop. But in reality, the biology underneath is far more complex—and if it’s ignored, the visible consequences can undermine the very goal people are trying to achieve. At Epic Genetics, that complexity is exactly where the work begins. A recent case study highlights this perfectly. Over just four weeks, an indiv

Mitochondrial health sits at the centre of nearly every longevity conversation. From energy production to metabolic flexibility and cellular resilience, the mitochondria ultimately determine how efficiently we age. One emerging intervention that has gained attention in both research and biohacking circles is MOTS-c, a mitochondrial-derived peptide believed to regulate metabolic stress and enhance cellular efficiency. While preclinical data is promising, real-world human data

Experimental Triple-Agonist Weight Loss Drug Experimental weight-loss drugs are spreading rapidly across social media, but the conversation is often dominated by dramatic before-and-after photos rather than detailed experiences. While compounds like semaglutide and tirzepatide have become widely known, a newer molecule— Retatrutide —is attracting attention for a different reason: it appears to increase metabolic rate rather than simply suppress appetite. Recently, a client sh

A Mitochondrial Repair Strategy Backed by Biomarkers Featuring Tony Pemberton - Founder Mitochondrial health is increasingly recognized as one of the most upstream drivers of aging and disease. While many longevity strategies focus on suppressing pathways like mTOR or improving metabolic markers, repairing mitochondrial dysfunction directly may be one of the most powerful interventions available today. One compound gaining significant attention in the biohacking and longevity

Featuring Tony Pemberton SLU-PP-332 has rapidly become one of the most discussed “exercise mimetic” compounds in the longevity and performance world. But despite the hype, one question still matters more than anything else: What is the right dose of SLU-PP-332? After reviewing my own biomarker data across multiple cycles, tracking glucose and cardio performance in real time, and seeing what happens when people push doses far too high, I’ve become increasingly convinced that m

Featuring Dr Ramona Varga – Nutritionist & Gut Expert Low mood, anxiety, and reduced motivation are often framed as purely psychological challenges. But modern functional medicine — especially when guided by epigenetic testing and gut microbiome analysis — tells a far more nuanced story. At Epic Genetics, we frequently see that mood-related symptoms are driven by biological signalling imbalances long before they become clinical diagnoses. This case highlights how combining

When people talk about cognitive enhancement, the conversation often drifts toward dopamine, stimulation, or short-term productivity. But long-term cognitive performance — especially in the context of aging, ADHD traits, and brain-health risk reduction — is much more about structural support + energy metabolism than chasing a feeling. That’s where uridine monophosphate, a choline donor (Alpha-GPC or citicoline), and acetyl-L-carnitine (ALCAR) come in. These are not hype ing

Reversing Borderline Prediabetes: What Continuous Glucose Monitors Are Teaching Us Borderline prediabetes often sits in an uncomfortable grey area. Blood markers aren’t yet “diabetic,” symptoms may be minimal, and as a result, many people delay action. But with the rise of continuous glucose monitors (CGMs), we’re now able to see—often for the first time—how daily decisions directly shape glucose control in real time. At Epic Genetics, we’ve been working with clients who sit

A Practical Personal Case Study on Finding the Optimal Dose Over Time featuring Tony Pemberton Epitalon is one of the most talked-about peptides in the longevity space, largely because of its ability to upregulate telomerase activity and, over time, influence telomere length. While the mechanism is compelling, dosing remains one of the most misunderstood aspects of Epitalon use. This article outlines practical Epitalon dosing strategies, what I’ve observed across multiple per

By Tony Pemberton, Founder Introduction: Why Immune Health Deserves Centre Stage When people think about longevity, they often focus on cardiovascular health, glucose control, or body composition. But the immune system is arguably one of the most powerful — and most overlooked — drivers of both lifespan and healthspan. Chronic immune dysfunction underpins accelerated ageing, increased cancer risk, recurrent infections, autoimmune disease, and poor recovery from stress. Fortun

Chronic, low-grade inflammation is one of the most underestimated drivers of accelerated ageing, metabolic dysfunction, and long-term disease risk. While weight-loss drugs such as Mounjaro (tirzepatide) are often seen as a quick fix, this case study highlights how strategic synergy —combining pharmacology, targeted supplementation, lifestyle optimisation, and epigenetic testing —can lead to profound and measurable improvements in inflammatory health. Using DNA methylation–b

How Epigenetic Testing and Advanced Health MOTs Can Reduce Long-Term Risk Cancer is not a single event—it is a long biological process driven by metabolic stress, chronic inflammation, toxic burden, mitochondrial dysfunction, immune imbalance, and dysregulated growth signalling. While genetics load the gun, epigenetics pulls the trigger . This is why modern cancer prevention and long-term maintenance is shifting away from symptom-based screening alone and towards epigenetic

Yes, You Can: Reversing Pre-Diabetes Through Food, Stress Control, and a “Younger-You” Lifestyle By Debbie Polisky, Nutritionist & Epigenetic Coach When people hear the word pre-diabetes , they often feel like they’re standing on the edge of a cliff. I get it — it sounds scary. But I want to reframe that for you straight away. Pre-diabetes is also a window . It’s a stage where your body is still incredibly responsive to the right daily inputs. And the best part? Those inputs

My Cycle, the Human Data, and How I’m Tracking Results By Tony Pemberton — Founder of Epic Genetics Mitochondrial health is one of those “deep-root” levers in aging and performance. If your mitochondria are inefficient, ATP production drops, reactive oxygen species rise, fatigue climbs, and downstream systems (kidney, heart, muscles, brain) start paying the price. That’s why I’ve been paying close attention to SS-31 — also known as elamipretide — a mitochondria-targeting tetr

How I Used the “Love Hormone” to Improve Blood Pressure, HRV & Pace of Aging By Tony Pemberton — Founder of Epic Genetics Most people only know oxytocin as the “love hormone.” But over the past few months, I’ve been running a structured oxytocin cycle—not for mood, not for bonding, but for its impact on inflammation, blood pressure, metabolic function, and biological aging . As someone who professionally analyses biomarkers through TrueDiagnostic epigenetic tests , runs Healt

Background The subject is a 13-year-old girl diagnosed with autism. She had previously missed a substantial period of schooling due to...

Background A client began their health optimisation journey with concerning lipid and cardiovascular biomarkers. Their most actionable...