Case Study: Transforming Cholesterol Health in 6 Months

Background A client began their health optimisation journey with concerning lipid and cardiovascular biomarkers. Their most actionable lipid biomarkers showed:

• ApoB: High

• Total Triglycerides: High

• ApoA1: Low

• HDL-C: Low

  
  

Genetic testing further suggested an increased risk of cardiovascular disease, taking into account his all lipid biomarkers. While ApoB has a strong genetic component, lifestyle and targeted interventions were explored to improve the broader lipid profile.

Intervention Strategy (6 months)

To address the biomarkers holistically, a combined approach of supplementation, nutrition, and lifestyle modification was implemented.

🔬 Supplementation

• Berberine Phytosome (1000mg/day): Supported insulin sensitivity, lowered triglycerides, and boosted HDL.

• Longvida Curcumin (400mg/day): Provided anti-inflammatory and mild lipid-lowering effects, with benefits for vascular health.

• Omega-3 Fatty Acids (3g/day): Significantly reduced triglycerides and improved lipoprotein particle quality.

• Plant Sterols (2g/day): Helped reduce intestinal cholesterol absorption and lower ApoB.

• Modified Citrus Pectin (1240mg/day): Added to support cholesterol binding in the gut, alongside potential anti-inflammatory benefits.

• Absorbable Tocotrienols (63mg/day): Assisted in lowering ApoB-containing lipoproteins.

🥗 Nutrition

• Reduced Saturated Fat: Cut back on red meat, dairy cream, butter, and coconut cream. Replaced with olive oil, avocado, nuts, and seeds.

• Increased Soluble Fibre: Included oats, beans, seaweed, lentils, flaxseed, and psyllium husk daily to bind bile acids and lower LDL.

• Lycopene-Rich Foods: Nearly daily use of tomato passata and purée increased lycopene intake, which has evidence for improving endothelial health and LDL resistance to oxidation.

• Polyphenol-Rich Foods: Regular intake of berries, pomegranate, and green tea to support HDL function and reduce inflammation.

• Carbohydrate & Alcohol Control: Minimised refined sugars and limited alcohol, further reducing triglyceride burden.

  
  

🏃 Lifestyle

• Cardiovascular Exercise: 90 minutes per week of moderate-intensity cardio to lower triglycerides and raise HDL.

• Resistance Training: 2–3 sessions per week to improve metabolic flexibility and overall lipid metabolism.

• Sleep Optimisation: 17 minute increase in 30 day avervage total of sleep time for better metabolic health and improved aging biomarkers.

Results (6 months later)

Repeat testing showed a substantial improvement:

• ApoB: Still high, but reduced slightly (genetic ceiling acknowledged).

• Triglycerides: Decreased by 50%, moving into a healthier range.

• ApoA1: Increased significantly, supporting reverse cholesterol transport.

• HDL-C: Improved from low to mid-range, further reducing cardiovascular risk.

• HBA1C: Dropped by approxiately 20% further improving metabolic health

  
  

ConclusionThis case illustrates that “DNA is not destiny”. While genetic predisposition set a baseline risk, targeted supplementation, dietary changes (including lycopene-rich foods and soluble fibre), and consistent lifestyle habits led to meaningful biomarker improvements in just six months.